Novel DNA Aptamers that Bind to Mutant Huntingtin and Modify Its Activity

The CAG repeat expansion that elongates the polyglutamine tract in huntingtin is the root genetic cause of Huntington’s disease (HD), a debilitating neurodegenerative disorder. This seemingly slight change to the primary amino acid sequence alters the physical structure of the mutant protein and alt...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Mol Ther Nucleic Acids
Prif Awduron: Shin, Baehyun, Jung, Roy, Oh, Hyejin, Owens, Gwen E., Lee, Hyeongseok, Kwak, Seung, Lee, Ramee, Cotman, Susan L., Lee, Jong-Min, MacDonald, Marcy E., Song, Ji-Joon, Vijayvargia, Ravi, Seong, Ihn Sik
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society of Gene & Cell Therapy 2018
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5992459/
https://ncbi.nlm.nih.gov/pubmed/29858077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2018.03.008
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