Htt CAG repeat expansion confers pleiotropic gains of mutant huntingtin function in chromatin regulation

The CAG repeat expansion in the Huntington's disease gene HTT extends a polyglutamine tract in mutant huntingtin that enhances its ability to facilitate polycomb repressive complex 2 (PRC2). To gain insight into this dominant gain of function, we mapped histone modifications genome-wide across...

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Publicado no:Hum Mol Genet
Main Authors: Biagioli, Marta, Ferrari, Francesco, Mendenhall, Eric M., Zhang, Yijing, Erdin, Serkan, Vijayvargia, Ravi, Vallabh, Sonia M., Solomos, Nicole, Manavalan, Poornima, Ragavendran, Ashok, Ozsolak, Fatih, Lee, Jong Min, Talkowski, Michael E., Gusella, James F., Macdonald, Marcy E., Park, Peter J., Seong, Ihn Sik
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4383859/
https://ncbi.nlm.nih.gov/pubmed/25574027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddv006
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