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Hdh(Q111) Mice Exhibit Tissue Specific Metabolite Profiles that Include Striatal Lipid Accumulation

The HTT CAG expansion mutation causes Huntington’s Disease and is associated with a wide range of cellular consequences, including altered metabolism. The mutant allele is expressed widely, in all tissues, but the striatum and cortex are especially vulnerable to its effects. To more fully understand...

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שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:PLoS One
Main Authors: Carroll, Jeffrey B., Deik, Amy, Fossale, Elisa, Weston, Rory M., Guide, Jolene R., Arjomand, Jamshid, Kwak, Seung, Clish, Clary B., MacDonald, Marcy E.
פורמט: Artigo
שפה:Inglês
יצא לאור: Public Library of Science 2015
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4546654/
https://ncbi.nlm.nih.gov/pubmed/26295712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0134465
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