Htt(Q111/+) Huntington’s Disease Knock-in Mice Exhibit Brain Region-Specific Morphological Changes and Synaptic Dysfunction

BACKGROUND: Successful disease-modifying therapy for Huntington’s disease (HD) will require therapeutic intervention early in the pathogenic process. Achieving this goal requires identifying phenotypes that are proximal to the HTT CAG repeat expansion. OBJECTIVE: To use Htt CAG knock-in mice, precis...

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Detalhes bibliográficos
Publicado no:J Huntingtons Dis
Main Authors: Kovalenko, Marina, Milnerwood, Austen, Giordano, James, St. Claire, Jason, Guide, Jolene R., Stromberg, Mary, Gillis, Tammy, Sapp, Ellen, DiFiglia, Marian, MacDonald, Marcy E., Carroll, Jeffrey B., Lee, Jong-Min, Tappan, Susan, Raymond, Lynn, Wheeler, Vanessa C.
Formato: Artigo
Idioma:Inglês
Publicado em: IOS Press 2018
Assuntos:
Research Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5869998/
https://ncbi.nlm.nih.gov/pubmed/29480209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JHD-170282
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