Genetic Contributors to Intergenerational CAG Repeat Instability in Huntington’s Disease Knock-In Mice

Huntington’s disease (HD) is a neurodegenerative disorder caused by the expansion of a CAG trinucleotide repeat in exon 1 of the HTT gene. Longer repeat sizes are associated with increased disease penetrance and earlier ages of onset. Intergenerationally unstable transmissions are common in HD famil...

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Vydáno v:Genetics
Hlavní autoři: Neto, João Luís, Lee, Jong-Min, Afridi, Ali, Gillis, Tammy, Guide, Jolene R., Dempsey, Stephani, Lager, Brenda, Alonso, Isabel, Wheeler, Vanessa C., Pinto, Ricardo Mouro
Médium: Artigo
Jazyk:Inglês
Vydáno: Genetics Society of America 2017
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Investigations
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5289832/
https://ncbi.nlm.nih.gov/pubmed/27913616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.116.195578
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