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Genetic Contributors to Intergenerational CAG Repeat Instability in Huntington’s Disease Knock-In Mice
Huntington’s disease (HD) is a neurodegenerative disorder caused by the expansion of a CAG trinucleotide repeat in exon 1 of the HTT gene. Longer repeat sizes are associated with increased disease penetrance and earlier ages of onset. Intergenerationally unstable transmissions are common in HD famil...
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| Pubblicato in: | Genetics |
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| Autori principali: | , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Genetics Society of America
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5289832/ https://ncbi.nlm.nih.gov/pubmed/27913616 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.116.195578 |
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