Disruption of Rab11 activity in a knock-in mouse model of Huntington's Disease

The Huntington's disease (HD) mutation causes polyglutamine expansion in huntingtin (Htt) and neurodegeneration. Htt interacts with a complex containing Rab11GDP and is involved in activation of Rab11, which functions in endosomal recycling and neurite growth and long-term potentiation. Like ot...

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Autors principals: Li, Xueyi, Sapp, Ellen, Chase, Kathryn, Comer-Tierney, Laryssa A., Masso, Nicholas, Alexander, Jonathan, Reeves, Patrick, Kegel, Kimberly B., Valencia, Antonio, Esteves, Miguel, Aronin, Neil, DiFiglia, Marian
Format: Artigo
Idioma:Inglês
Publicat: 2009
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2798579/
https://ncbi.nlm.nih.gov/pubmed/19699304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2009.08.003
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