Elevated NADPH oxidase activity contributes to oxidative stress and cell death in Huntington's disease

A mutation in the huntingtin (Htt) gene produces mutant Htt and Huntington's disease (HD), a neurodegenerative disorder. HD patients have oxidative damage in the brain, but the causes are unclear. Compared with controls, we found brain levels of NADPH oxidase (NOX) activity, which produces reac...

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Autores principales: Valencia, Antonio, Sapp, Ellen, Kimm, Jeffrey S., McClory, Hollis, Reeves, Patrick B., Alexander, Jonathan, Ansong, Kwadwo A., Masso, Nicholas, Frosch, Matthew P., Kegel, Kimberly B., Li, Xueyi, DiFiglia, Marian
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2013
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3578411/
https://ncbi.nlm.nih.gov/pubmed/23223017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/dds516
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