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Elevated NADPH oxidase activity contributes to oxidative stress and cell death in Huntington's disease
A mutation in the huntingtin (Htt) gene produces mutant Htt and Huntington's disease (HD), a neurodegenerative disorder. HD patients have oxidative damage in the brain, but the causes are unclear. Compared with controls, we found brain levels of NADPH oxidase (NOX) activity, which produces reac...
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| Autors principals: | , , , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Oxford University Press
2013
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3578411/ https://ncbi.nlm.nih.gov/pubmed/23223017 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/dds516 |
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