Glucose transporter 3 is a rab11-dependent trafficking cargo and its transport to the cell surface is reduced in neurons of CAG140 Huntington’s disease mice

Huntington’s disease (HD) disturbs glucose metabolism in the brain by poorly understood mechanisms. HD neurons have defective glucose uptake, which is attenuated upon enhancing rab11 activity. Rab11 regulates numerous receptors and transporters trafficking onto cell surfaces; its diminished activity...

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Publicado en:Acta Neuropathol Commun
Autores principales: McClory, Hollis, Williams, Dana, Sapp, Ellen, Gatune, Leah W, Wang, Ping, DiFiglia, Marian, Li, Xueyi
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4297405/
https://ncbi.nlm.nih.gov/pubmed/25526803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-014-0178-7
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