Glucose transporter 3 is a rab11-dependent trafficking cargo and its transport to the cell surface is reduced in neurons of CAG140 Huntington’s disease mice

Huntington’s disease (HD) disturbs glucose metabolism in the brain by poorly understood mechanisms. HD neurons have defective glucose uptake, which is attenuated upon enhancing rab11 activity. Rab11 regulates numerous receptors and transporters trafficking onto cell surfaces; its diminished activity...

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Bibliographic Details
Published in:Acta Neuropathol Commun
Main Authors: McClory, Hollis, Williams, Dana, Sapp, Ellen, Gatune, Leah W, Wang, Ping, DiFiglia, Marian, Li, Xueyi
Format: Artigo
Language:Inglês
Published: BioMed Central 2014
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4297405/
https://ncbi.nlm.nih.gov/pubmed/25526803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-014-0178-7
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