The COOH-terminal domain of huntingtin interacts with RhoGEF kalirin and modulates cell survival

Human huntingtin (Htt) contains 3144 amino acids and has an expanded polyglutamine region near the NH(2)-terminus in patients with Huntington’s disease. While numerous binding partners have been identified to NH(2)-terminal Htt, fewer proteins are known to interact with C-terminal domains of Htt. He...

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Publicat a:Sci Rep
Autors principals: McClory, Hollis, Wang, Xiaolong, Sapp, Ellen, Gatune, Leah W., Iuliano, Maria, Wu, Chiu-Yi, Nathwani, Gina, Kegel-Gleason, Kimberly B., DiFiglia, Marian, Li, Xueyi
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5964228/
https://ncbi.nlm.nih.gov/pubmed/29789657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-26255-1
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