Mutant Huntingtin Impairs Vesicle Formation from Recycling Endosomes by Interfering with Rab11 Activity

Huntingtin (Htt) localizes to endosomes, but its role in the endocytic pathway is not established. Recently, we found that Htt is important for the activation of Rab11, a GTPase involved in endosomal recycling. Here we studied fibroblasts of healthy individuals and patients with Huntington's di...

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Detalhes bibliográficos
Main Authors: Li, Xueyi, Standley, Clive, Sapp, Ellen, Valencia, Antonio, Qin, Zheng-Hong, Kegel, Kimberly B., Yoder, Jennifer, Comer-Tierney, Laryssa A., Esteves, Miguel, Chase, Kathryn, Alexander, Jonathan, Masso, Nicholas, Sobin, Lindsay, Bellve, Karl, Tuft, Richard, Lifshitz, Lawrence, Fogarty, Kevin, Aronin, Neil, DiFiglia, Marian
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2772576/
https://ncbi.nlm.nih.gov/pubmed/19752198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00420-09
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