Mutant Huntingtin Impairs Vesicle Formation from Recycling Endosomes by Interfering with Rab11 Activity

Huntingtin (Htt) localizes to endosomes, but its role in the endocytic pathway is not established. Recently, we found that Htt is important for the activation of Rab11, a GTPase involved in endosomal recycling. Here we studied fibroblasts of healthy individuals and patients with Huntington's di...

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Autores principales: Li, Xueyi, Standley, Clive, Sapp, Ellen, Valencia, Antonio, Qin, Zheng-Hong, Kegel, Kimberly B., Yoder, Jennifer, Comer-Tierney, Laryssa A., Esteves, Miguel, Chase, Kathryn, Alexander, Jonathan, Masso, Nicholas, Sobin, Lindsay, Bellve, Karl, Tuft, Richard, Lifshitz, Lawrence, Fogarty, Kevin, Aronin, Neil, DiFiglia, Marian
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology (ASM) 2009
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2772576/
https://ncbi.nlm.nih.gov/pubmed/19752198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00420-09
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