Native Mutant Huntingtin in Human Brain: EVIDENCE FOR PREVALENCE OF FULL-LENGTH MONOMER

Huntington disease (HD) is caused by polyglutamine expansion in the N terminus of huntingtin (htt). Analysis of human postmortem brain lysates by SDS-PAGE and Western blot reveals htt as full-length and fragmented. Here we used Blue Native PAGE (BNP) and Western blots to study native htt in human po...

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Detalhes bibliográficos
Main Authors: Sapp, Ellen, Valencia, Antonio, Li, Xueyi, Aronin, Neil, Kegel, Kimberly B., Vonsattel, Jean-Paul, Young, Anne B., Wexler, Nancy, DiFiglia, Marian
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Neurobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3339996/
https://ncbi.nlm.nih.gov/pubmed/22375012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.286609
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