Huntingtin Bodies Sequester Vesicle-Associated Proteins by a Polyproline-Dependent Interaction

Polyglutamine expansion in the N terminus of huntingtin (htt) causes selective neuronal dysfunction and cell death by unknown mechanisms. Truncated htt expressed in vitro produced htt immunoreactive cytoplasmic bodies (htt bodies). The fibrillar core of the mutant htt body resisted protease treatmen...

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Опубликовано в: :J Neurosci
Главные авторы: Qin, Zheng-Hong, Wang, Yumei, Sapp, Ellen, Cuiffo, Benjamin, Wanker, Erich, Hayden, Michael R., Kegel, Kimberly B., Aronin, Neil, DiFiglia, Marian
Формат: Artigo
Язык:Inglês
Опубликовано: Society for Neuroscience 2004
Предметы:
Neurobiology of Disease
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6729557/
https://ncbi.nlm.nih.gov/pubmed/14715959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1409-03.2004
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