Huntingtin Bodies Sequester Vesicle-Associated Proteins by a Polyproline-Dependent Interaction

Polyglutamine expansion in the N terminus of huntingtin (htt) causes selective neuronal dysfunction and cell death by unknown mechanisms. Truncated htt expressed in vitro produced htt immunoreactive cytoplasmic bodies (htt bodies). The fibrillar core of the mutant htt body resisted protease treatmen...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Qin, Zheng-Hong, Wang, Yumei, Sapp, Ellen, Cuiffo, Benjamin, Wanker, Erich, Hayden, Michael R., Kegel, Kimberly B., Aronin, Neil, DiFiglia, Marian
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2004
Assuntos:
Neurobiology of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6729557/
https://ncbi.nlm.nih.gov/pubmed/14715959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1409-03.2004
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