Huntingtin Bodies Sequester Vesicle-Associated Proteins by a Polyproline-Dependent Interaction

Polyglutamine expansion in the N terminus of huntingtin (htt) causes selective neuronal dysfunction and cell death by unknown mechanisms. Truncated htt expressed in vitro produced htt immunoreactive cytoplasmic bodies (htt bodies). The fibrillar core of the mutant htt body resisted protease treatmen...

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Bibliografiska uppgifter
I publikationen:J Neurosci
Huvudupphovsmän: Qin, Zheng-Hong, Wang, Yumei, Sapp, Ellen, Cuiffo, Benjamin, Wanker, Erich, Hayden, Michael R., Kegel, Kimberly B., Aronin, Neil, DiFiglia, Marian
Materialtyp: Artigo
Språk:Inglês
Publicerad: Society for Neuroscience 2004
Ämnen:
Neurobiology of Disease
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6729557/
https://ncbi.nlm.nih.gov/pubmed/14715959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1409-03.2004
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