Huntingtin Expression Stimulates Endosomal–Lysosomal Activity, Endosome Tubulation, and Autophagy

An expansion of polyglutamines in the N terminus of huntingtin causes Huntington's disease (HD) and results in the accrual of mutant protein in the nucleus and cytoplasm of affected neurons. How mutant huntingtin causes neurons to die is unclear, but some recent observations suggest that an aut...

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Bibliografiske detaljer
Udgivet i:J Neurosci
Main Authors: Kegel, Kimberly B., Kim, Manho, Sapp, Ellen, McIntyre, Charmian, Castaño, José G., Aronin, Neil, DiFiglia, Marian
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2000
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ARTICLE
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6772788/
https://ncbi.nlm.nih.gov/pubmed/11007884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.20-19-07268.2000
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