Huntingtin Expression Stimulates Endosomal–Lysosomal Activity, Endosome Tubulation, and Autophagy

An expansion of polyglutamines in the N terminus of huntingtin causes Huntington's disease (HD) and results in the accrual of mutant protein in the nucleus and cytoplasm of affected neurons. How mutant huntingtin causes neurons to die is unclear, but some recent observations suggest that an aut...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Kegel, Kimberly B., Kim, Manho, Sapp, Ellen, McIntyre, Charmian, Castaño, José G., Aronin, Neil, DiFiglia, Marian
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2000
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ARTICLE
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6772788/
https://ncbi.nlm.nih.gov/pubmed/11007884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.20-19-07268.2000
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