Caspase 3-cleaved N-terminal fragments of wild-type and mutant huntingtin are present in normal and Huntington's disease brains, associate with membranes, and undergo calpain-dependent proteolysis

The Huntington's disease (HD) mutation is a polyglutamine expansion in the N-terminal region of huntingtin (N-htt). How neurons die in HD is unclear. Mutant N-htt aggregates in neurons in the HD brain; expression of mutant N-htt in vitro causes cell death. Other in vitro studies show that prote...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Kim, Yun J., Yi, Yong, Sapp, Ellen, Wang, Yumei, Cuiffo, Ben, Kegel, Kimberly B., Qin, Zheng-Hong, Aronin, Neil, DiFiglia, Marian
Médium: Artigo
Jazyk:Inglês
Vydáno: The National Academy of Sciences 2001
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC60131/
https://ncbi.nlm.nih.gov/pubmed/11675509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.221451398
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky