Rac1 Activity Is Modulated by Huntingtin and Dysregulated in Models of Huntington’s Disease

BACKGROUND: Previous studies suggest that Huntingtin, the protein mutated in Huntington’s disease (HD), is required for actin based changes in cell morphology, and undergoes stimulus induced targeting to plasma membranes where it interacts with phospholipids involved in cell signaling. The small GTP...

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Bibliografske podrobnosti
izdano v:J Huntingtons Dis
Main Authors: Tousley, Adelaide, Iuliano, Maria, Weisman, Elizabeth, Sapp, Ellen, Zhang, Ningzhe, Vodicka, Petr, Alexander, Jonathan, Aviolat, Hubert, Gatune, Leah, Reeves, Patrick, Li, Xueyi, Khvorova, Anastasia, Ellerby, Lisa M., Aronin, Neil, DiFiglia, Marian, Kegel-Gleason, Kimberly B.
Format: Artigo
Jezik:Inglês
Izdano: IOS Press 2019
Teme:
Research Report
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6398565/
https://ncbi.nlm.nih.gov/pubmed/30594931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JHD-180311
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