Rac1 Activity Is Modulated by Huntingtin and Dysregulated in Models of Huntington’s Disease

BACKGROUND: Previous studies suggest that Huntingtin, the protein mutated in Huntington’s disease (HD), is required for actin based changes in cell morphology, and undergoes stimulus induced targeting to plasma membranes where it interacts with phospholipids involved in cell signaling. The small GTP...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:J Huntingtons Dis
Main Authors: Tousley, Adelaide, Iuliano, Maria, Weisman, Elizabeth, Sapp, Ellen, Zhang, Ningzhe, Vodicka, Petr, Alexander, Jonathan, Aviolat, Hubert, Gatune, Leah, Reeves, Patrick, Li, Xueyi, Khvorova, Anastasia, Ellerby, Lisa M., Aronin, Neil, DiFiglia, Marian, Kegel-Gleason, Kimberly B.
פורמט: Artigo
שפה:Inglês
יצא לאור: IOS Press 2019
נושאים:
Research Report
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC6398565/
https://ncbi.nlm.nih.gov/pubmed/30594931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JHD-180311
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