Rac1 Activity Is Modulated by Huntingtin and Dysregulated in Models of Huntington’s Disease

BACKGROUND: Previous studies suggest that Huntingtin, the protein mutated in Huntington’s disease (HD), is required for actin based changes in cell morphology, and undergoes stimulus induced targeting to plasma membranes where it interacts with phospholipids involved in cell signaling. The small GTP...

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Xehetasun bibliografikoak
Argitaratua izan da:J Huntingtons Dis
Egile Nagusiak: Tousley, Adelaide, Iuliano, Maria, Weisman, Elizabeth, Sapp, Ellen, Zhang, Ningzhe, Vodicka, Petr, Alexander, Jonathan, Aviolat, Hubert, Gatune, Leah, Reeves, Patrick, Li, Xueyi, Khvorova, Anastasia, Ellerby, Lisa M., Aronin, Neil, DiFiglia, Marian, Kegel-Gleason, Kimberly B.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: IOS Press 2019
Gaiak:
Research Report
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6398565/
https://ncbi.nlm.nih.gov/pubmed/30594931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JHD-180311
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