Autophagy Activation by Transcription Factor EB (TFEB) in Striatum of HD(Q175/Q7) Mice

Background: Mutant huntingtin (mHTT) is encoded by the Huntington’s disease (HD) gene and its accumulation in the brain contributes to HD pathogenesis. Reducing mHTT levels through activation of the autophagosome-lysosomal pathway may have therapeutic benefit. Transcription factor EB (TFEB) regulate...

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Detalhes bibliográficos
Publicado no:J Huntingtons Dis
Main Authors: Vodicka, Petr, Chase, Kathryn, Iuliano, Maria, Tousley, Adelaide, Valentine, Dana T., Sapp, Ellen, Kegel-Gleason, Kimberly B., Sena-Esteves, Miguel, Aronin, Neil, DiFiglia, Marian
Formato: Artigo
Idioma:Inglês
Publicado em: IOS Press 2016
Assuntos:
Research Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5088406/
https://ncbi.nlm.nih.gov/pubmed/27689619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JHD-160211
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