Autophagy Activation by Transcription Factor EB (TFEB) in Striatum of HD(Q175/Q7) Mice

Background: Mutant huntingtin (mHTT) is encoded by the Huntington’s disease (HD) gene and its accumulation in the brain contributes to HD pathogenesis. Reducing mHTT levels through activation of the autophagosome-lysosomal pathway may have therapeutic benefit. Transcription factor EB (TFEB) regulate...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:J Huntingtons Dis
Auteurs principaux: Vodicka, Petr, Chase, Kathryn, Iuliano, Maria, Tousley, Adelaide, Valentine, Dana T., Sapp, Ellen, Kegel-Gleason, Kimberly B., Sena-Esteves, Miguel, Aronin, Neil, DiFiglia, Marian
Format: Artigo
Langue:Inglês
Publié: IOS Press 2016
Sujets:
Research Report
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5088406/
https://ncbi.nlm.nih.gov/pubmed/27689619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JHD-160211
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires