Mutant Huntingtin Impairs Vesicle Formation from Recycling Endosomes by Interfering with Rab11 Activity

Huntingtin (Htt) localizes to endosomes, but its role in the endocytic pathway is not established. Recently, we found that Htt is important for the activation of Rab11, a GTPase involved in endosomal recycling. Here we studied fibroblasts of healthy individuals and patients with Huntington's di...

Full description

Saved in:
Bibliographic Details
Main Authors: Li, Xueyi, Standley, Clive, Sapp, Ellen, Valencia, Antonio, Qin, Zheng-Hong, Kegel, Kimberly B., Yoder, Jennifer, Comer-Tierney, Laryssa A., Esteves, Miguel, Chase, Kathryn, Alexander, Jonathan, Masso, Nicholas, Sobin, Lindsay, Bellve, Karl, Tuft, Richard, Lifshitz, Lawrence, Fogarty, Kevin, Aronin, Neil, DiFiglia, Marian
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2009
Subjects:
Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2772576/
https://ncbi.nlm.nih.gov/pubmed/19752198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00420-09
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items