Expanded Polyglutamine-containing N-terminal Huntingtin Fragments Are Entirely Degraded by Mammalian Proteasomes

Huntington disease is a neurodegenerative disorder caused by an expanded polyglutamine (polyQ) repeat within the protein huntingtin (Htt). N-terminal fragments of the mutant Htt (mHtt) proteins containing the polyQ repeat are aggregation-prone and form intracellular inclusion bodies. Improving the c...

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Detalhes bibliográficos
Main Authors: Juenemann, Katrin, Schipper-Krom, Sabine, Wiemhoefer, Anne, Kloss, Alexander, Sanz Sanz, Alicia, Reits, Eric A. J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3779707/
https://ncbi.nlm.nih.gov/pubmed/23908352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.486076
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