Expanded-Polyglutamine Huntingtin Protein Suppresses the Secretion and Production of a Chemokine (CCL5/RANTES) by Astrocytes

Huntington's disease (HD) is a hereditary neurological disease caused by expended CAG repeats in the HD gene, which codes for a protein called Huntingtin (Htt). The resultant mutant Huntingtin (mHtt) forms aggregates in neurons and causes neuronal dysfunction. In astrocytes, the largest populat...

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Publicado no:J Neurosci
Main Authors: Chou, Szu-Yi, Weng, Ju-Yun, Lai, Hsing-Lin, Liao, Fang, Sun, Synthia H., Tu, Pang-Hsien, Dickson, Dennis W., Chern, Yijuang
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2008
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6670608/
https://ncbi.nlm.nih.gov/pubmed/18367595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0116-08.2008
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