Interaction with Polyglutamine-expanded Huntingtin Alters Cellular Distribution and RNA Processing of Huntingtin Yeast Two-hybrid Protein A (HYPA)

Huntington disease (HD) is an autosomal inherited disorder that causes the deterioration of brain cells. The polyglutamine (polyQ) expansion of huntingtin (Htt) is implicated in the pathogenesis of HD via interaction with an RNA splicing factor, Htt yeast two-hybrid protein A/forming-binding protein...

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Main Authors: Jiang, Ya-Jun, Che, Mei-Xia, Yuan, Jin-Qiao, Xie, Yuan-Yuan, Yan, Xian-Zhong, Hu, Hong-Yu
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2011
Ábhair:
Molecular Bases of Disease
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3137094/
https://ncbi.nlm.nih.gov/pubmed/21566141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.216333
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