Interaction with Polyglutamine-expanded Huntingtin Alters Cellular Distribution and RNA Processing of Huntingtin Yeast Two-hybrid Protein A (HYPA)

Huntington disease (HD) is an autosomal inherited disorder that causes the deterioration of brain cells. The polyglutamine (polyQ) expansion of huntingtin (Htt) is implicated in the pathogenesis of HD via interaction with an RNA splicing factor, Htt yeast two-hybrid protein A/forming-binding protein...

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Detalhes bibliográficos
Main Authors: Jiang, Ya-Jun, Che, Mei-Xia, Yuan, Jin-Qiao, Xie, Yuan-Yuan, Yan, Xian-Zhong, Hu, Hong-Yu
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3137094/
https://ncbi.nlm.nih.gov/pubmed/21566141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.216333
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