Interaction with Polyglutamine-expanded Huntingtin Alters Cellular Distribution and RNA Processing of Huntingtin Yeast Two-hybrid Protein A (HYPA)

Huntington disease (HD) is an autosomal inherited disorder that causes the deterioration of brain cells. The polyglutamine (polyQ) expansion of huntingtin (Htt) is implicated in the pathogenesis of HD via interaction with an RNA splicing factor, Htt yeast two-hybrid protein A/forming-binding protein...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Jiang, Ya-Jun, Che, Mei-Xia, Yuan, Jin-Qiao, Xie, Yuan-Yuan, Yan, Xian-Zhong, Hu, Hong-Yu
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Society for Biochemistry and Molecular Biology 2011
Θέματα:
Molecular Bases of Disease
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3137094/
https://ncbi.nlm.nih.gov/pubmed/21566141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.216333
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