Interaction with Polyglutamine-expanded Huntingtin Alters Cellular Distribution and RNA Processing of Huntingtin Yeast Two-hybrid Protein A (HYPA)

Huntington disease (HD) is an autosomal inherited disorder that causes the deterioration of brain cells. The polyglutamine (polyQ) expansion of huntingtin (Htt) is implicated in the pathogenesis of HD via interaction with an RNA splicing factor, Htt yeast two-hybrid protein A/forming-binding protein...

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Bibliographic Details
Main Authors: Jiang, Ya-Jun, Che, Mei-Xia, Yuan, Jin-Qiao, Xie, Yuan-Yuan, Yan, Xian-Zhong, Hu, Hong-Yu
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2011
Subjects:
Molecular Bases of Disease
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3137094/
https://ncbi.nlm.nih.gov/pubmed/21566141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.216333
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