N-terminal Huntingtin (Htt) phosphorylation is a molecular switch regulating Htt aggregation, helical conformation, internalization, and nuclear targeting

Huntington's disease is a fatal neurodegenerative disorder resulting from a CAG repeat expansion in the first exon of the gene encoding the Huntingtin protein (Htt). Phosphorylation of this protein region (Httex1) has been shown to play important roles in regulating the structure, toxicity, and...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Biol Chem
Prif Awduron: DeGuire, Sean M., Ruggeri, Francesco S., Fares, Mohamed-Bilal, Chiki, Anass, Cendrowska, Urszula, Dietler, Giovanni, Lashuel, Hilal A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2018
Pynciau:
Molecular Bases of Disease
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6290154/
https://ncbi.nlm.nih.gov/pubmed/30185623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.004621
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