TBK1 phosphorylates mutant Huntingtin and suppresses its aggregation and toxicity in Huntington's disease models

Phosphorylation of the N‐terminal domain of the huntingtin (HTT) protein has emerged as an important regulator of its localization, structure, aggregation, clearance and toxicity. However, validation of the effect of bona fide phosphorylation in vivo and assessing the therapeutic potential of target...

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Detalhes bibliográficos
Publicado no:EMBO J
Principais autores: Hegde, Ramanath Narayana, Chiki, Anass, Petricca, Lara, Martufi, Paola, Arbez, Nicolas, Mouchiroud, Laurent, Auwerx, Johan, Landles, Christian, Bates, Gillian P, Singh‐Bains, Malvindar K, Dragunow, Mike, Curtis, Maurice A, Faull, Richard LM, Ross, Christopher A, Caricasole, Andrea, Lashuel, Hilal A
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7459410/
https://ncbi.nlm.nih.gov/pubmed/32757223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2020104671
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