Phospho-S129 Alpha-Synuclein Is Present in Human Plasma but Not in Cerebrospinal Fluid as Determined by an Ultrasensitive Immunoassay

Accumulation and aggregation of misfolded alpha-synuclein is believed to be a cause of Parkinson’s disease (PD). Phosphorylation of alpha-synuclein at S129 is known to be associated with the pathological misfolding process, but efforts to investigate the relevance of this post-translational modifica...

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Publicat a:Front Neurosci
Autors principals: Cariulo, Cristina, Martufi, Paola, Verani, Margherita, Azzollini, Lucia, Bruni, Giordana, Weiss, Andreas, Deguire, Sean M., Lashuel, Hilal A., Scaricamazza, Eugenia, Sancesario, Giulia Maria, Schirinzi, Tommaso, Mercuri, Nicola Biagio, Sancesario, Giuseppe, Caricasole, Andrea, Petricca, Lara
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2019
Matèries:
Neuroscience
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6714598/
https://ncbi.nlm.nih.gov/pubmed/31507364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2019.00889
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