Phosphorylation of huntingtin at residue T3 is decreased in Huntington’s disease and modulates mutant huntingtin protein conformation

Posttranslational modifications can have profound effects on the biological and biophysical properties of proteins associated with misfolding and aggregation. However, their detection and quantification in clinical samples and an understanding of the mechanisms underlying the pathological properties...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Cariulo, Cristina, Azzollini, Lucia, Verani, Margherita, Martufi, Paola, Boggio, Roberto, Chiki, Anass, Deguire, Sean M., Cherubini, Marta, Gines, Silvia, Marsh, J. Lawrence, Conforti, Paola, Cattaneo, Elena, Santimone, Iolanda, Squitieri, Ferdinando, Lashuel, Hilal A., Petricca, Lara, Caricasole, Andrea
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2017
Assuntos:
PNAS Plus
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5740681/
https://ncbi.nlm.nih.gov/pubmed/29162692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1705372114
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares