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Validation of Ultrasensitive Mutant Huntingtin Detection in Human Cerebrospinal Fluid by Single Molecule Counting Immunoassay

BACKGROUND: The measurement of disease-relevant biomarkers has become a major component of clinical trial design, but in the absence of rigorous clinical and analytical validation of detection methodology, interpretation of results may be misleading. In Huntington’s disease (HD), measurement of the...

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Bibliografiske detaljer
Udgivet i:J Huntingtons Dis
Main Authors: Fodale, Valentina, Boggio, Roberto, Daldin, Manuel, Cariulo, Cristina, Spiezia, Maria Carolina, Byrne, Lauren M., Leavitt, Blair R., Wild, Edward J., Macdonald, Douglas, Weiss, Andreas, Bresciani, Alberto
Format: Artigo
Sprog:Inglês
Udgivet: IOS Press 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5757651/
https://ncbi.nlm.nih.gov/pubmed/29125493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JHD-170269
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