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Analysis of mutant and total huntingtin expression in Huntington’s disease murine models

Huntington’s disease (HD) is a monogenetic neurodegenerative disorder that is caused by the expansion of a polyglutamine region within the huntingtin (HTT) protein, but there is still an incomplete understanding of the molecular mechanisms that drive pathology. Expression of the mutant form of HTT i...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Fodale, Valentina, Pintauro, Roberta, Daldin, Manuel, Altobelli, Roberta, Spiezia, Maria Carolina, Bisbocci, Monica, Macdonald, Douglas, Bresciani, Alberto
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7746729/
https://ncbi.nlm.nih.gov/pubmed/33335120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-78790-5
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