Mutant huntingtin fragmentation in immune cells tracks Huntington’s disease progression

Huntington’s disease (HD) is a fatal, inherited neurodegenerative disorder caused by an expanded CAG repeat in the gene encoding huntingtin (HTT). Therapeutic approaches to lower mutant HTT (mHTT) levels are expected to proceed to human trials, but noninvasive quantification of mHTT is not currently...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Weiss, Andreas, Träger, Ulrike, Wild, Edward J., Grueninger, Stephan, Farmer, Ruth, Landles, Christian, Scahill, Rachael I., Lahiri, Nayana, Haider, Salman, Macdonald, Douglas, Frost, Chris, Bates, Gillian P., Bilbe, Graeme, Kuhn, Rainer, Andre, Ralph, Tabrizi, Sarah J.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Clinical Investigation 2012
Aiheet:
Brief Report
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3461928/
https://ncbi.nlm.nih.gov/pubmed/22996692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI64565
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