Mutant huntingtin fragmentation in immune cells tracks Huntington’s disease progression

Huntington’s disease (HD) is a fatal, inherited neurodegenerative disorder caused by an expanded CAG repeat in the gene encoding huntingtin (HTT). Therapeutic approaches to lower mutant HTT (mHTT) levels are expected to proceed to human trials, but noninvasive quantification of mHTT is not currently...

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Détails bibliographiques
Auteurs principaux: Weiss, Andreas, Träger, Ulrike, Wild, Edward J., Grueninger, Stephan, Farmer, Ruth, Landles, Christian, Scahill, Rachael I., Lahiri, Nayana, Haider, Salman, Macdonald, Douglas, Frost, Chris, Bates, Gillian P., Bilbe, Graeme, Kuhn, Rainer, Andre, Ralph, Tabrizi, Sarah J.
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2012
Sujets:
Brief Report
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3461928/
https://ncbi.nlm.nih.gov/pubmed/22996692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI64565
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