Validation of Ultrasensitive Mutant Huntingtin Detection in Human Cerebrospinal Fluid by Single Molecule Counting Immunoassay

BACKGROUND: The measurement of disease-relevant biomarkers has become a major component of clinical trial design, but in the absence of rigorous clinical and analytical validation of detection methodology, interpretation of results may be misleading. In Huntington’s disease (HD), measurement of the...

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Detalhes bibliográficos
Publicado no:J Huntingtons Dis
Main Authors: Fodale, Valentina, Boggio, Roberto, Daldin, Manuel, Cariulo, Cristina, Spiezia, Maria Carolina, Byrne, Lauren M., Leavitt, Blair R., Wild, Edward J., Macdonald, Douglas, Weiss, Andreas, Bresciani, Alberto
Formato: Artigo
Idioma:Inglês
Publicado em: IOS Press 2017
Assuntos:
Research Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5757651/
https://ncbi.nlm.nih.gov/pubmed/29125493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JHD-170269
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