Polyglutamine Tract Expansion Increases S-Nitrosylation of Huntingtin and Ataxin-1

Expansion of the polyglutamine (polyQ) tract in the huntingtin (Htt) protein causes Huntington’s disease (HD), a fatal inherited movement disorder linked to neurodegeneration in the striatum and cortex. S-nitrosylation and S-acylation of cysteine residues regulate many functions of cytosolic protein...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Ni, Chun-Lun, Seth, Divya, Fonseca, Fabio Vasconcelos, Wang, Liwen, Xiao, Tsan Sam, Gruber, Phillip, Sy, Man-Sun, Stamler, Jonathan S., Tartakoff, Alan M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5033456/
https://ncbi.nlm.nih.gov/pubmed/27658206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0163359
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