PRMT5- mediated symmetric arginine dimethylation is attenuated by mutant huntingtin and is impaired in Huntington's disease (HD)

Abnormal protein interactions of mutant huntingtin (Htt) triggered by polyglutamine expansion are thought to mediate Huntington's disease (HD) pathogenesis. Here, we explored a functional interaction of Htt with protein arginine methyltransferase 5 (PRMT5), an enzyme mediating symmetrical dimet...

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Detalhes bibliográficos
Publicado no:Cell Cycle
Main Authors: Ratovitski, Tamara, Arbez, Nicolas, Stewart, Jacqueline C, Chighladze, Ekaterine, Ross, Christopher A
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2015
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Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4615115/
https://ncbi.nlm.nih.gov/pubmed/25927346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2015.1033595
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