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Effects of oncogenic mutations on the conformational free-energy landscape of EGFR kinase
Activating mutations in the epidermal growth factor receptor (EGFR) tyrosine kinase are frequently found in many cancers. It has been suggested that changes in the equilibrium between its active and inactive conformations are linked to its oncogenic potential. Here, we quantify the effects of some o...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3696764/ https://ncbi.nlm.nih.gov/pubmed/23754386 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1221953110 |
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