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Transitions to catalytically inactive conformations in EGFR kinase
The epidermal growth factor receptor (EGFR) is a key protein in cellular signaling, and its kinase domain (EGFR kinase) is an intensely pursued target of small-molecule drugs. Although both catalytically active and inactive conformations of EGFR kinase have been resolved crystallographically, experi...
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| Autores principales: | , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
National Academy of Sciences
2013
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3645566/ https://ncbi.nlm.nih.gov/pubmed/23576739 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1220843110 |
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