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The Activation of c-Src Tyrosine Kinase: Conformational Transition Pathway and Free Energy Landscape

Tyrosine kinases are important cellular signaling allosteric enzymes that regulate cell growth, proliferation, metabolism, differentiation and migration. Their activity must be tightly regulated, and disruption of this regulation can lead to a variety of diseases, particularly cancer. The non-recept...

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書目詳細資料
發表在:J Phys Chem B
Main Authors: Fajer, Mikolai, Meng, Yilin, Roux, Benoît
格式: Artigo
語言:Inglês
出版: 2016
主題:
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5398919/
https://ncbi.nlm.nih.gov/pubmed/27715044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jpcb.6b08409
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