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The Activation of c-Src Tyrosine Kinase: Conformational Transition Pathway and Free Energy Landscape
Tyrosine kinases are important cellular signaling allosteric enzymes that regulate cell growth, proliferation, metabolism, differentiation and migration. Their activity must be tightly regulated, and disruption of this regulation can lead to a variety of diseases, particularly cancer. The non-recept...
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| Udgivet i: | J Phys Chem B |
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| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5398919/ https://ncbi.nlm.nih.gov/pubmed/27715044 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jpcb.6b08409 |
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