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The Activation of c-Src Tyrosine Kinase: Conformational Transition Pathway and Free Energy Landscape
Tyrosine kinases are important cellular signaling allosteric enzymes that regulate cell growth, proliferation, metabolism, differentiation and migration. Their activity must be tightly regulated, and disruption of this regulation can lead to a variety of diseases, particularly cancer. The non-recept...
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| 出版年: | J Phys Chem B |
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| 主要な著者: | , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2016
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5398919/ https://ncbi.nlm.nih.gov/pubmed/27715044 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jpcb.6b08409 |
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