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On the importance of a funneled energy landscape for the assembly and regulation of multidomain Src tyrosine kinases
Regulation of signaling pathways in the cell often involves multidomain allosteric enzymes that are able to adopt alternate active or inactive conformations in response to specific stimuli. It is therefore of great interest to elucidate the energetic and structural determinants that govern the confo...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2007
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1959435/ https://ncbi.nlm.nih.gov/pubmed/17699616 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0704041104 |
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