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Flexibility and charge asymmetry in the activation loop of Src tyrosine kinases

Regulated activity of Src kinases is critical for cell growth. Src kinases can be activated by trans-phosphorylation of a tyrosine located in the central activation loop of the catalytic domain. However, because the required exposure of this tyrosine is not observed in the down-regulated X-ray struc...

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Bibliografiske detaljer
Main Authors: Banavali, Nilesh K., Roux, Benoît
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2770843/
https://ncbi.nlm.nih.gov/pubmed/18623061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.22153
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