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Flexibility and charge asymmetry in the activation loop of Src tyrosine kinases
Regulated activity of Src kinases is critical for cell growth. Src kinases can be activated by trans-phosphorylation of a tyrosine located in the central activation loop of the catalytic domain. However, because the required exposure of this tyrosine is not observed in the down-regulated X-ray struc...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2009
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2770843/ https://ncbi.nlm.nih.gov/pubmed/18623061 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.22153 |
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