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Locking the Active Conformation of c-Src Kinase through the Phosphorylation of the Activation Loop
Molecular dynamics umbrella sampling simulations are used to compare the relative stability of the active conformation of the catalytic domain of c-Src kinase while the tyrosine 416 in the activation loop (A-loop) is either unphosphorylated or phosphorylated. When the A-loop is unphosphorylated, the...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3947352/ https://ncbi.nlm.nih.gov/pubmed/24103328 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2013.10.001 |
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