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Computational Study of the “DFG-Flip” Conformational Transition in c-Abl and c-Src Tyrosine Kinases

[Image: see text] Protein tyrosine kinases are crucial to cellular signaling pathways regulating cell growth, proliferation, metabolism, differentiation, and migration. To maintain normal regulation of cellular signal transductions, the activities of tyrosine kinases are also highly regulated. The c...

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Bibliographic Details
Published in:J Phys Chem B
Main Authors: Meng, Yilin, Lin, Yen-lin, Roux, Benoît
Format: Artigo
Language:Inglês
Published: American Chemical Society 2014
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4315421/
https://ncbi.nlm.nih.gov/pubmed/25548962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jp511792a
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