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Computational study of the W260A activating mutant of Src tyrosine kinase

Tyrosine kinases are enzymes playing a critical role in cellular signaling. Mutations causing increased in kinase activity are often associated with cancer and various pathologies. One example in Src tyrosine kinases is offered by the substitution of the highly conserved tryptophan 260 by an alanine...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Protein Sci
Egile Nagusiak: Meng, Yilin, Roux, Benoît
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: John Wiley and Sons Inc. 2015
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4815304/
https://ncbi.nlm.nih.gov/pubmed/26106037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2731
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