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Computational study of the W260A activating mutant of Src tyrosine kinase

Tyrosine kinases are enzymes playing a critical role in cellular signaling. Mutations causing increased in kinase activity are often associated with cancer and various pathologies. One example in Src tyrosine kinases is offered by the substitution of the highly conserved tryptophan 260 by an alanine...

詳細記述

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書誌詳細
出版年:Protein Sci
主要な著者: Meng, Yilin, Roux, Benoît
フォーマット: Artigo
言語:Inglês
出版事項: John Wiley and Sons Inc. 2015
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4815304/
https://ncbi.nlm.nih.gov/pubmed/26106037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2731
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