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Computational study of the W260A activating mutant of Src tyrosine kinase
Tyrosine kinases are enzymes playing a critical role in cellular signaling. Mutations causing increased in kinase activity are often associated with cancer and various pathologies. One example in Src tyrosine kinases is offered by the substitution of the highly conserved tryptophan 260 by an alanine...
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| 發表在: | Protein Sci |
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| Main Authors: | , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
John Wiley and Sons Inc.
2015
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4815304/ https://ncbi.nlm.nih.gov/pubmed/26106037 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2731 |
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