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Transition path theory analysis of c-Src kinase activation

Nonreceptor tyrosine kinases of the Src family are large multidomain allosteric proteins that are crucial to cellular signaling pathways. In a previous study, we generated a Markov state model (MSM) to simulate the activation of c-Src catalytic domain, used as a prototypical tyrosine kinase. The lon...

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Bibliografiset tiedot
Julkaisussa:Proc Natl Acad Sci U S A
Päätekijät: Meng, Yilin, Shukla, Diwakar, Pande, Vijay S., Roux, Benoît
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 2016
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Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4995974/
https://ncbi.nlm.nih.gov/pubmed/27482115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1602790113
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