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Src Kinase Conformational Activation: Thermodynamics, Pathways, and Mechanisms
Tyrosine kinases of the Src-family are large allosteric enzymes that play a key role in cellular signaling. Conversion of the kinase from an inactive to an active state is accompanied by substantial structural changes. Here, we construct a coarse-grained model of the catalytic domain incorporating e...
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| Hauptverfasser: | , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Public Library of Science
2008
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2268010/ https://ncbi.nlm.nih.gov/pubmed/18369437 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1000047 |
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