Architecture of the MKK6-p38α complex defines the basis of MAPK specificity and activation

The mitogen-activated protein kinase (MAPK) p38α is a central component of signaling in inflammation and the immune response and is, therefore, an important drug target. Little is known about the molecular mechanism of its activation by double phosphorylation from MAPK kinases (MAP2Ks), because of t...

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Publicado no:Science
Main Authors: Juyoux, Pauline, Galdadas, Ioannis, Gobbo, Dorothea, von Velsen, Jill, Pelosse, Martin, Tully, Mark, Vadas, Oscar, Gervasio, Francesco Luigi, Pellegrini, Erika, Bowler, Matthew W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2023
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7615176/
https://ncbi.nlm.nih.gov/pubmed/37708276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.add7859
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