Architecture of the MKK6-p38α complex defines the basis of MAPK specificity and activation

The mitogen-activated protein kinase (MAPK) p38α is a central component of signaling in inflammation and the immune response and is, therefore, an important drug target. Little is known about the molecular mechanism of its activation by double phosphorylation from MAPK kinases (MAP2Ks), because of t...

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Bibliografski detalji
Izdano u:Science
Glavni autori: Juyoux, Pauline, Galdadas, Ioannis, Gobbo, Dorothea, von Velsen, Jill, Pelosse, Martin, Tully, Mark, Vadas, Oscar, Gervasio, Francesco Luigi, Pellegrini, Erika, Bowler, Matthew W.
Format: Artigo
Jezik:Inglês
Izdano: 2023
Teme:
Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7615176/
https://ncbi.nlm.nih.gov/pubmed/37708276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.add7859
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